转自：康龙化成

康龙化成举办第五十六期“合成与药物化学前沿”名师线上讲座

2025年6月26日，北京——华盛顿大学的Kevin Moeller教授做客康龙化成第五十六期“合成与药物化学前沿”名师线上讲座，报告主题为“从分子到分子表面，开发电化学与合成的协同作用”。报告重点介绍了：1）如何设计新的极反转反应并将其应用到一系列氧化反应；2）在聚合物包覆的微电极阵列上进行位点选择反应，监测小分子与生物靶标之间的相互结合作用；3）通过开发新的化学电极在合成反应中引入选择性的新机会。

首先，Kevin Moeller教授引用Manuel Baizer教授的话为出发点，指出了电化学技术在科学家们不断的努力下，取得了一定的发展和进步。Kevin Moeller教授阐明了电化学和有机合成相互促进发展，并希望通过他们课题组在电化学领域不断的探索，开发新的电化学技术，进而为合成化学家提供便利。Kevin Moeller教授深入浅出地介绍了极反转电化学并将其应用到一系列氧化反应中，如氧化环化反应和醇的氧化等，并将其应用到(+)-神经烯酸和外排抑制剂黄孢嗪的合成。

然后，Kevin Moeller教授介绍了抗生素耐药性的现状以及自组装单层膜技术（SAM）的稳定性，表面合成和表征的反应数量有限，与高密度阵列的兼容性，以及设备类型的通用性存在的局限性与挑战。因此，设计了聚合物包覆的微电极阵列，希望通过位点选择反应（氧化还原反应、Diels-Alder Reaction和Chan-Lam Coupling等），监测小分子与生物靶标之间的相互结合，进而发挥一定的分析和诊断作用。

最后，Kevin Moeller教授展示了新设计的化学电极在选择性合成反应中的应用。通过新设计的化学电极，选择性实现化学分子的识别，将电解反应限制在电极表面，为合成和开发用于研究电极上发生的过程的化学探针提供了新的机会。

会后，Kevin Moeller教授在问答环节中与听众进行了热烈的讨论。

Frontiers in Synthetic and Medicinal Chemistry

--The 56th Pharmaron Virtual Lecture

Beijing, China, June 26, 2025 - Pharmaron held its 56th virtual lecture in the Frontiers of Synthetic and Medicinal Chemistry series, delivered by Prof. Kevin Moellerfrom Washington University in St. Louis. The presentation was titled “From Molecules to Molecular Surfaces and Back Again. Exploiting the Synergy Between Electrochemistry and Synthesis.” The talk focused on three areas: 1) How to design new pole-reversal reactions and apply them to a series of oxidation reactions; 2) Conduct site selective reactions on a polymer coated microelectrode arrays and monitor binding interactions between small molecules and biological targets; 3) Introduce new opportunities for selectivity in synthetic reactions by developing new chemical electrodes.

Professor Kevin Moeller started his talk by noting that Professor Manuel Baizer played a significant role in the development of electrochemical technology. Professor Moeller stated that electrochemistry and organic synthesis can foster development of new electrochemical techniques through the continuous exploration of their research group in the field of electrochemistry, which will provide support for synthetic chemists. Professor Kevin Moeller introduced pole-reversal electrochemistry in a simple and understandable way and applied it to a series of oxidation reactions, such as oxidative cyclization reactions and the oxidation of alcohols, and also applied it to the synthesis of (+)-nemorensic acid and the efflux inhibitors Chrysosporazines.

Professor Kevin Moeller then introduced the current situation of antibiotic resistance and the limitations. He also discussed the challenges existing in the stability of self-assembled monolayer film technology (SAM), the limited number of reactions for surface synthesis and characterization, compatibility with high-density arrays, and the universality of equipment types. He explained that a polymer-coated microelectrode array was designed, with the goal to monitor the interaction between small molecules and biological targets through site selection reactions (Redox reactions, Diels-Alder reactions and Chan-Lam Coupling, etc.), and thereby play a certain role in analysis and diagnosis.

Finally, Professor Kevin Moeller demonstrated the application of the newly designed chemical electrode in selective synthesis reactions. By designing new chemical electrodes, the selective recognition of chemical molecules was achieved, and the electrolytic reaction was restricted to the electrode surface, provides new opportunities for the synthesis and development of chemical probes for studying the processes occurring on the electrodes.

After the meeting, Professor Kevin Moeller had a lively discussion with the audience in the Q&A session.

（转自：康龙化成）